免疫组学研究
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桥本甲状腺炎患者自身免疫抗体与超声弹性成像评分的相关性

李湘琪、冉章申、孙锡波、王瑛、魏昌然

Objective: To investigate the correlation between autoimmune antibodies, ultrasonic elasticity score, and elasticity coefficient in patients with Hashimoto’s Thyroiditis (HT).

Methods: The thyroid function, the titer of the Thyroid globulin Antibody (TgAb) and Thyroid Peroxides Antibody (TPOAb) were detected by chemiluminescence method from the fasting serum of 258 patients suffering with HT; the ultrasonic elasticity score and elasticity coefficient were evaluated after detecting the patients’ thyroid with GELOGIQ3 type color doppler ultrasound diagnostic system and getting a satisfactory elastosonography. Then the correlation between autoimmune antibodies, ultrasonic elasticity score and elasticity coefficient were analyzed respectively.

Results: Serum Thyroid Stimulating Hormone (TSH), TGA and TPO in 258 patients with HT increased significantly, the titer of TgAb was positively correlated with elastic coefficient, r=0.62, P<0.01, and also positively correlated with the elastic score, r=0.65, P<0.01; TPOAb was positively correlated with elastic coefficient, r=0.63, P<0.01, and positively correlated with elastic score as well, r=0.62, P<0.01.

Conclusions: It’s helpful to increase the accuracy rate of HT diagnosis with the detection of thyroid autoimmune function combined with real-time ultrasound elastosonography score.