妇产科学
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医用臭氧对扭转-扭转实验模型中卵巢功能和组织病理学特征的治疗作用

Yakup Baykus、Rulin Deniz、Yasemen Adali、Fatih Kara、Omur Ozturk、Suna Aydin、Suleyman Aydin

背景：卵巢扭转是一种严重的妇科疾病，尤其是在育龄期。医用臭氧具有抗氧化、抗凋亡和抗炎特性，具有治疗作用。

Objective: This study aimed to determine the effects of medical ozone on the ovarian functions and ovarian morphology in an experimental rat ovarian torsion-detorsion model.

Methods: Twenty female Wistar albino rats were used in this study. The rats were randomized into two groups: Group 1 (torsion/detorsion+ozone) (n=10) and Group 2 (only torsion/detorsion) (n=10). Histopathological evaluation of the ovarian tissue was performed. Additionally, Total Antioxidant Capacity (TAC), Follicle-Stimulating Hormone (FSH), Estradiol (E2), and Lactate Dehydrogenase (LDH) levels were measured in the serum.

Results: Ozone application has to lead to a decrease in histopathological parameters such as hemorrhage, vascular congestion, cellular apoptosis, and necrosis while no histopathological changes were detected concerning edema and inflammatory cells. High TAC in Group 1 and high FSH in Group 2 were detected. A statistically significant difference between the two groups was detected in terms of TAC (p=0.001) and FSH (p=0.002). There were no significant differences between Group1 and Group2 regarding E2 (p=0.757), and LDH levels (p=0.453).

结论：医用臭氧对细胞损伤的组织病理学标志物有积极影响，并增加扭转-扭转模型的抗氧化能力。我们建议可以设计进一步的动物模型研究来揭示医用臭氧影响背后的因素。