国际标准期刊号: 2161-0665
Farida El Baz、Mged A. El-Setouhy、Wessam Ahmed Mouharam、Ahmed M. Abdel Raouf 和 Azza M. Youssef
背景:自闭症是一种神经发育障碍,其特征是社交互动、语言和非语言交流受损,以及行为受限和刻板。铅中毒被认为是自闭症的一个可能的危险因素。
Aim: Investigate the relation between blood lead levels and autism in a sample of Egyptian autistic children, and to correlate these levels with severity of the disease.
Patients and methods: This case-control study was conducted on 51 participants, 31 autistic patients diagnosed based on DSM-IV criteria recruited from child and adolescent Psychiatry Clinic, Children Hospital, Ain Shams University and 20 controls. Blood Lead level was measured by for the whole studied population.
结果:自闭症儿童的平均血铅水平高于对照组,但无统计学显着差异。研究发现,患者年龄、智商和血铅水平之间存在负相关,但患者性别、母亲使用补牙材料、抗产抗 D 注射、母亲大量食用鱼类、分娩方式、分娩方式等方面没有统计学意义。患者和对照组之间的产后并发症。
结论:虽然自闭症儿童的血铅水平正常,但由于自闭症儿童的排毒能力较差,因此他们可能容易受到铅的影响。此外,血铅水平并不代表总负荷,因为铅可以储存在骨骼中。