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Charge reversal derivatization enhances dicarboxylic acid quantification using liquid chromatography tandem mass spectrometry.

Alfred Fonteh*, Joby Jose

Analysis of Dicarboxylic Acids (DCAs) in biofluids is important in biomarker discovery studies since DCAs play key roles in various physiologic functions. Low concentrations of some DCAs in body fluids require sensitive detection methods for quantification. Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS) with chemical charge-reversal provides a sensitive means of quantifying low DCA levels.