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外用枸橼酸西地那非溶液与外用米诺地尔5%治疗女性型脱发的疗效和安全性对比研究

Heba Abdo Mostafa1*、Hassan Abou Khodair Mohammed2、Ibrahim Fouda2

背景：女性型脱发 (FPHL) 是一种非疤痕性进行性头发稀疏，头发数量逐渐减少，特别是在额叶、中央和顶叶头皮。受影响区域的终毛脱落通常是不完全的，额发际线通常不受影响。它是由毛囊微型化引起的，这是一个逐渐减少终毛与毳毛比例的过程。

工作目的：评估外用 1% 枸橼酸西地那非溶液与外用米诺地尔 5% 泡沫治疗女性型脱发的疗效和安全性。

患者和方法：这项探索性试点研究包括 30 名患有女性型脱发的女性患者。纳入的患者分为 2 组；

第 1 组：接受 1% 局部柠檬酸西地那非溶液。

第 2 组：接受 5% 局部米诺地尔泡沫。

使用毛发镜检查来评估治疗反应。

结果： In group 1 (treated with topical sildenafil 1%): There was a statistically significant increase in the vellus hair count in the frontal region, vertex and temporal side after treatment as compared to before treatment. Also, there was statistically significant increase in the terminal hair count in the frontal region and vertex region after treatment as compared to before treatment. There was no statistically significant difference in the hair thickness in all the regions after treatment, group 2 (treated with topical minoxidil 5%) there was a statistically significant increase in the terminal hair count and hair thickness in the frontal region, vertex and temporal side after treatment as compared to before treatment. Also, there was statistically significant decrease in the vellus hair count, but it was detected only in the frontal region.

结论：外用 1% 西地那非治疗被证明是治疗 FPHL 的良好替代方案，尽管外用 5% 米诺地尔仍是 FPHL 治疗的首选。