真菌基因组学与生物学
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Evaluation of Antibacterial Activities of Endophytic Fungus Chaetomium jodhapurense Isolated from Medicinal Plant Tridax procumbens (L.)

Charde KS, Shahare NH *

Tridax procumbens (L.) is a promising species that produces secondary metabolites reported to have a variety of medicinal uses including among others, anti-anemic, anti-inflammatory, anti-diabetic, and anesthetic properties. Endophytes are plant-associated microorganisms that live within the living tissues of their host plants without causing any harm to them. They stimulate the production of secondary metabolites with a diverse range of biological activities. The objective of the present research was to investigate fungal endophytes harboring in the tissues of the medicinal plant Tridax procumbens (L.) and assess its antimicrobial activity. In the present research article one of the isolated endophytic fungus Chaetomium jodhapurense was evaluated for its antibacterial potential. To isolate the endophytic fungus, the surface sterilization method was used. The isolate was identified on the basis of morphological characters and molecular analysis. The isolate was then cultivated on potato dextrose broth for 3 weeks and aqueous extract was analyzed for antibacterial activity against five bacterial strains i.e., Staphylococcus aureus (ATCC-6538), Klebsiella pneumonia (ATCC-4352), Escherichia coli (ATCC-8739), Streptococcus pneumoniae (ATCC-6303) and Salmonella typhimurium (ATCC-14028). The aqueous extract (25 ul) of the endophytic fungus Chaetomium jodhapurense showed broad-spectrum activity against five human pathogenic bacteria.