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正常胎儿和生长受限胎儿的胎儿肾体积和胎儿多普勒：是否存在相关性？

Manal Mohamed El Behery、Moustafa A Ibrahiem、Soha Siam 和 Mohmoud A Seksaka

目的：评估脐动脉、大脑中动脉和胎儿肾动脉多普勒是否会影响妊娠 26 周后健康胎儿和生长受限胎儿的胎儿肾脏体积。

设计：前瞻性横断面研究。

地点：埃及扎加齐格大学妇产科。

样本： 100 名孕妇，其中 77 名胎儿生长参数正常，43 名胎儿 IUGR。

方法：使用二维超声测量胎儿肾体积、合并肾体积和相对肾体积。检查脐动脉、大脑中动脉和胎儿肾动脉多普勒指数。

主要结果指标：多普勒参数与胎儿肾脏体积的相关性，以及胎儿生物识别指数与胎儿肾脏合并体积的关联。

Results: Combined and relative fetal kidney volume was significantly reduced in growth restricted fetuses than in normally grown fetuses 29% (95% CI, 18%-37%), for the former and 18% (95% CI, 3%-22) for the latter. All fetal biometric indices were positively associated with combined kidney volume. The largest effects were found for estimated fetal weight and abdominal circumference after adjustment for gestational age. No correlation exists between umbilical or middle cerebral artery Doppler and fetal renal volume. A significant negative correlation was found between fetal renal artery pulsatility index and fetal renal volume after adjustment for abdominal circumference.

结论：生长受限胎儿的胎儿肾动脉搏动指数增加与胎儿肾脏体积呈负相关，导致肾脏灌注减少和肾生成受损。