生物学与医学高级技术
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深入了解功能性红霉素/抗氧化剂含有壳聚糖水凝胶作为潜在生物活性修复材料的结构、功能和抗菌活性

Perchyonok VT，张S，Basson N，Grobler S，

文献中提供了大量关于活性氧 (ROS) 和抗氧化剂在炎症等疾病和类风湿性关节炎等慢性免疫介导疾病中的作用的数据。然而，关于牙周病的信息却非常少，牙周病显示出其他慢性炎症性疾病的许多病理特征。牙周组织还提供了一种理想的介质，通过非侵入性收集 GCF，研究 ROS 介导的组织损伤和响应细菌定植的抗氧化防御机制。生物粘附聚合物似乎对于开发替代性无蚀刻牙本质粘合系统特别有吸引力，该系统具有额外的治疗递送系统的额外优势，以在必要时改善治疗剂和预防剂的牙内给药。壳聚糖是一种生物安全的生物聚合物，已被提议作为一种生物粘附聚合物，并且由于其独特的性能和在其他人和我们最近报道的广泛口腔应用中的灵活性而引起我们的持续兴趣。本研究的目的是评估基于壳聚糖的新型功能性药物递送系统，该系统可以成功地融入到含有常见抗生素（如红霉素、磷虾油、芦荟和阿司匹林）作为常用抗氧化剂的“双重作用生物活性修复材料”中。

Methods: The novel hydrogels will be investigated with respect to the antioxidant capacity and drug release capacity of the tetracycline as well as erythromycin from the designer drug delivery system, the use of SEM imaging for the characterization of the surfaces and reactive features of novel materials with antimicrobial potential as well as
use of the newly designed materials as an effective adhesive restorative materials.

Results: A continuous release of erythromycin, while maintaining antibiotic effects against the tested bacteria,for at least 24 hours was shown from designer chitosan-antioxidant hydrogels. The increase antioxidant capacityof the designer material, significant antimicrobial capacity as well as adhesive dentine bond strength make the
chitosan-containing restorative materials suitable and potentially advantageous materials for restorative and
periodontal applications in-vitro. The addition of antioxidants to the functionalized restorative material acts as a
alternative free radical defense mechanism and therefor increases the shear bond strength teeth by managing the
excess of free radicals produced during common restorative procedure. Future investigations are necessary to
验证这个假设。