药物保健与健康系统杂志
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甲硝唑片在不同液体存在下的体外悬浮排列

基兰·比克拉姆·博哈拉

甲硝唑是一种常用的抗感染药，与硝基咪唑类抗微生物药一起占有一席之地。它经常被用来将胃肠道污染视为滴虫病、贾第鞭毛虫病和阿米巴病等寄生虫病。甲硝唑长期以来一直被用作抗毒素，其抗寄生虫特性使其有别于许多其他抗菌药物，使其能够治疗多种疾病。它有盒式结构、片剂式结构、外用式结构、栓剂式结构，可用于治疗不同的疾病。
 

甲硝唑从小消化道通过口腔组织迅速被吸收，包括传播到所有组织和液体。在肝脏中通过氧化和与葡萄糖醛酸腐蚀物的结合过程进行消化。它会随着尿液消失，半衰期结束 7-8 小时。通常以 400-800 mg 薄膜包衣片剂形式提供，并显示与酒类药物的沟通。大量研究表明，很大一部分药物与各种主食、药物、饮料、果汁和生态复合剂有关。许多药物与天然产物挤压相关，例如二氢吡啶、特非那定、沙奎那韦、环孢素、咪达唑仑、三唑仑和维拉帕米、麦角胺、尼莫地平、氟伏沙明、可待因、曲马多、羟考酮、氢可酮、卡马西平、伊马替尼、洛哌丁胺、氯沙坦、右美沙芬、瑞格列奈、丁螺环酮、胺碘酮、决奈达隆、奎尼丁、丙吡胺、普罗帕酮、卡维地洛、西沙必利、非洛地平、尼卡地平、地苯地平、尼索地平、尼群地平、西地那非、他达拉非、伐地那非、二氢可待因、奥美拉唑、唑吡坦、美沙酮、曲唑酮、吡喹酮, 阿苯达唑,洛伐他汀、阿司咪唑、甲苯咪唑等。体外崩解是药物从片剂网格中释放出来并冲压以随后胃肠道吸收的关键能力。药物从片剂网格中的体外崩解取决于多种成分，其中包括药物的理化性质、定义性质和程序组合。因此，体外崩解研究扩大了保证产品质量的重要参数，就像识别相同操作者的细节一样。体外崩解研究是评估定义的关键手段，同样可以了解与明确的胃肠道状况、部分倾倒以及食物对生物利用度和与不同药物的配合的影响相关的潜在危险。在孟加拉国，有许多组织提供甲硝唑薄膜包衣片并进行广告宣传。除了国内品牌外，市场上还出现了一些国际品牌。
 

Normal reactions incorporate queasiness, a metallic taste, loss of craving, and migraines. Once in a while seizures or sensitivities to the drug may happen. Some express that metronidazole ought not be utilized in early pregnancy, while others state portions for trichomoniasis are sheltered Sources differ over security in breastfeeding.

 

The specific component of activity of metronidazole has not been completely settled, in any case, it is conceivable that a middle of the road in the decrease of metronidazole which is just made by anaerobic microorganisms and protozoa, ties deoxyribonucleic corrosive and electron-transport proteins of creatures, blocking nucleic corrosive synthesis.14 After organization, metronidazole enters cells by inactive dissemination. Following this, ferredoxin or flavodoxin lessen its nitro gathering to nitro radicals. The redox capability of the electron transport bits of anaerobic or microaerophilic microorganisms renders metronidazole specific to these life forms, which cause nitro bunch decrease, prompting the creation of poisonous metabolites. These incorporate N-(2-hydroxyethyl) oxamic corrosive and acetamide, which may harm DNA of repeating living beings

 

Metronidazole experiences hepatic digestion through hydroxylation, oxidation, and glucuronidation. The digestion of metronidazole yields 5 metabolites. The hydroxy metabolite, 1-(2-hydroxy-ethyl)- 2-hydroxy methyl-5-nitroimidazole, is viewed as the significant dynamic metabolite.7,13 Unchanged metronidazole is found in the plasma alongside limited quantities of its 2-hydroxymethyl metabolite. A few metabolites of metronidazole are found in the pee. They are fundamentally a result of side-bind oxidation notwithstanding glucuronide conjugation. Just 20% of the portion found in the pee is represented by unaltered metronidazole. The two fundamental oxidative metabolites of metronidazole are hydroxy and acidic corrosive metabolites.
 

In vitro disintegration study was proceeded according to referenced in Indian pharmacopeia. For the investigation of study we utilized graph pad crystal variant 8 and Microsoft exceed expectations. ANOVA followed by Dunnett's test was performed for the examination of % tranquilize discharge in various liquids. Distinctive disintegration medium were set up from 200ml of liquids and 700ml of 0.1 N HCl. In lentil soup (mung bean) disintegration of metronidazole tablet (78.69±1.89) doesn't accumulated with IP determination which is altogether diminished when contrasted and normal mean % sedate discharge on standard disintegration medium (0.1N HCl). When contrasted and standard disintegration medium, there is essentially decline % tranquilize discharge in rice water, watermelon juice, mango juice, pomegranate squeeze, dark and green tea yet values were inside the particulars.