肿瘤研究杂志
开放获取

抽象的

血管内皮生长因子 +936C/T 多态性对结肠癌患者肿瘤生长模式和生存的预后影响

阿布拉尔·艾哈迈德、尼古拉斯·韦尼泽洛斯和维多利亚·哈恩-斯特龙伯格

Introduction: Vascular endothelial growth factor (VEGF) is considered as endothelial cell-specific mitogen that plays an important role in the process of angiogenesis, thereby affecting the prognosis of tumor as angiogenesis is a crucial phase in tumor growth and metastasis. Accordingly, we carried out a case-control study to assess whether VEGF rs3025039 polymorphism affects the growth pattern and susceptibility to colon carcinoma.

Materials and methods: One hundred and fifty, formaline fixed paraffin embedded (FFPE) tissue samples from patients diagnosed with colon carcinoma and the same number of blood controls were used in the present study. VEGF +936 C>T (rs3025039) polymorphism was evaluated by pyrosequencing. Computer image analysis was used to analyse the growth pattern of the colon carcinoma tumor by using cytokeratin-8 stained slides.

结果：与纯合基因型（CC 和 TT）相比，rs3025039 多态性中的杂合基因型 TC 被发现是一种显着的保护性基因型。然而，我们发现所研究的多态性、肿瘤生长模式、5 年生存率和其他临床病理参数之间没有显着相关性。结论：我们得出结论，VEGF rs3025039 多态性的异源基因型似乎是结肠癌的保护因素，可以成为后续研究中的有用标记，并且可能是结肠癌的遗传决定因素。