药物保健与健康系统杂志
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临床药剂师在阿比让队列中降低抗逆转录病毒药物患者风险的作用

Djadji ATL、Kamenan BAT、Kassi NAC、Guehi C、Bekegran C 和 Eholie SP

简介：发展中国家获得抗逆转录病毒治疗的人数迅速增加，也带来了新的挑战。临床药剂师的风险管理可以改善资源匮乏的艾滋病毒患者的健康状况。我们评估了药物相互作用的风险标准，以告知临床医生。方法：这项横向工作包括开始接受 ART 治疗的患者。2015 年 1 月至 8 月，HIV 血清阳性者到传染病和热带疾病中心就诊 Unit of Treichville teaching Hospital at Abidjan. The guidelines for entry into the antiretroviral program has been used. All the coprescribed drugs were screened for potential for Drugs-Drugs significate interactions using the Liverpool HIV Pharmacology Group website (www.hiv-druginteractions.org). Also many others books and website have been used to analyse drugs interactions. Finally, the French Clinical pharmacy guideline allowed to stratify the pharmaceutical interventions. Results: Of 562 patients screened, 228 patients were included in the final analysis, comprising 91(39.91%) male and 137(60.9%) females; aged between 35-48 years (median 41 years), unmarried 160(63.18%), 218(95.61%) HIV1, 117(51.75%) with TB, renal failure 21(9.27%), First line of antiretroviral therapy 198 (86.84%) and 27(11.6%) patients were on second line treatment, Stage C (62.39%), mean Body mass index at baseline of 17.5.1 kg/m2 (range 35-48 kg). Baseline CD4 counts were 200 (IQR 25-75%) (Range 131.5-278) cells/mm3.The use of 1st line regimens were as follows: TDF/3TC/EFV in 141 patients (61.34%). Antiretroviral were prescribed at standard doses, regardless of whether a CR was present or not. Physiopathology stage was identified in 83 patients (36.41%) and potential drugs-drugs interactions with antiretroviral were identified in in 145 patients (63.59%) involving anti infectives for systemic use and 抗寄生虫产品131种（79.88%），传统植物18种（10.98%）。发现潜在的相互作用120(52.63%)、禁忌25(10.96%)和生物监测130(57.02%)其次是替代/交换47(20.61%)。结论：药剂师在管理患者健康方面的作用对于降低与 HIV 相关的死亡率或发病率非常重要。