自闭症-开放获取
开放获取

抽象的

Role of Gut Microbiota in the Developmental Regression of Autism

Jinru Cui, Heli Li, Cong Hu, Dandan Wu, Hao Li, Xiaoping Luo, Yan Hao*

About 1/3 of autistic children experienced Developmental Regression (DR), a special subtype of Autism Spectrum Disorder (ASD) governed by heredity, environment and their interaction. With in-depth study of gut microbiota, a close association between the imbalance of gut microbiota in early life and the incidence of ASD in infants has been established. Brain development and gut microbial stability occur almost at the age of 2 to 3 years old, that is, the age at which DR occurs. Therefore, the manner in which gut microbiota imbalance affects DR in autistic children is currently a research hotspot, given that the close association between gut microbiota and ASD in infants has been established. This review firstly summarizes the mechanisms involved in the brain processes of autistic children with DR, including gene regulation, Mitochondrial Dysfunction (MD), oxidative stress and immune inflammatory reaction. Secondly, it focuses on gut microbiota’s role in it so as to provide reference for early clinical identification and intervention in autistic children with DR.