蛋白质组学与生物信息学杂志
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Covid-19相关基因与人体内表达基因之间相互作用的研究

古斯塔沃·西蒙斯·嘉年华利

Covid 19 is a viral disease that emerged in China in December 2019 and has already spread throughout the world, with a high mortality and a high proliferation rates. It currently consists of a major focus of study, and among recent studies, one presented a set of 94 genes expressed in the human body with influence on Covid 19. The aim of this study is to understand the interaction of these 94 genes with other genes expressed in the human body, characterizing their properties by means of a gene expression network containing thousands of genes expressed in the human body. This characterization may concern a diverse set of properties. This study enabled the discovery of a limited set of genes with a regulatory role and a high influence on the human genes. The analysis also showed that although the 94 genes linked to Covid 19 may integrate several distinct metabolic pathways, they present great participation in only two main groups. Thus, this study has deepened the understanding on the genetic functioning of Covid 19 and may support explanations on the phenomena related to the disease, such as its high proliferation or the various phenotypic side effects caused by it. The author would also like to thank Capes, Fapemig and UFMG for the funding.