儿科学与治疗
开放获取

抽象的

吉达 KAMC 超重和肥胖儿童用药剂量不当的患病率

Aeshah Alazmi、曼苏尔汗、Loei Goronfolah 和 Rayf Abulezz

超重和肥胖在沙特阿拉伯人口中相当普遍。超重或肥胖的儿童可能会出现错误的药物剂量。先前的研究表明，儿童中最常见的用药错误类型是由于剂量不正确造成的。因此，我们计划开展这项研究，以调查吉达阿卜杜勒阿齐兹国王医疗中心 (KAMC) 儿科门诊儿童超重和肥胖的患病率以及研究人群药物剂量的适当性。

研究目的：确定超重和肥胖儿童中不适当药物剂量的患病率，并估计儿童超重和肥胖的患病率。

方法：本研究为一项回顾性研究，纳入2012年6月至12月普通儿科门诊就诊的2-18岁超重和肥胖儿童。所有患者均采用美国疾病控制中心的体重指数（BMI）和预防 (CDC) 儿科生长图表，显示就诊时记录的体重和身高的年龄和性别。描述性统计用于总结定量变量，而定性变量则用比例和百分比进行总结。不适当的剂量是使用 KAMC-Jeddah 现有批准的儿科参考文献（Lexi-Comp 的儿科和新生儿剂量手册）确定的，并分为剂量过量和剂量不足。

Results: Two thousand four hundred sixty patients aged from 2-18 years were screened using BMI to determine the prevalence of overweight and obesity. Results showed that 174 children were either overweight or obese. Only 96/174 patients (55%) who were overweight or obese have received medications. We found that the rate of overweight and obesity among males was 42% and 58% and among female were 48% and 52%. Only 96 patients out of 174 (55%) who were either obese or overweight received medications. The overall prevalence of an inappropriate medication dose prescribed in overweight and obese children was 63 out of 96 patients (66%). Over- dosage was observed in 32/63 (51%) and under dosage was found in 31/63 medications(49%).

结论：我国儿童群体中超重和肥胖的患病率日益引起人们的关注。应针对特定适应症使用基于体重的剂量，以确保超重和肥胖儿童的剂量方案正确且安全，除非儿童剂量超过推荐的成人剂量。我们没有评估临床结果，但是，超重和肥胖儿童治疗失败或不良反应的风险可能增加。