临床与实验眼科学杂志

临床与实验眼科学杂志
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国际标准期刊号: 2155-9570

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The Role of PI3K Isoforms in Ocular Angiogenesis

Dongwei Lai, Baiqi Liu, Linqing Xiong, Yiwei Yin, Xiaobo Xia, Wenyi Wu

Ocular angiogenesis is an important contributor to many vision-decreasing diseases, such as retinopathy of prematurity, proliferative diabetic retinopathy, as well as age-related macular degeneration. Understanding the molecular mechanism of angiogenesis has advanced the development of effective medicine in preventing ocular neovascularization. Phosphoinositide 3 kinases (PI3Ks), a main downstream of growth factors, are a family of lipases that are evolutionarily conserved in their ability to regulate cell growth and survival as well as migration and metabolism. Much evidence showed that it also plays a significant role in angiogenesis. Here, we review the distinct functions of class I PI3Ks in the canonical angiogenic pathway and its potential mechanism as a novel therapeutic target in ocular pathological angiogenesis.

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