头发疗法与移植
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Treating Frontal Fibrosing Alopecia with Regenerative Approaches: A Case Report

Luciana Donaire Passoni1, Beatriz Silva Rabelo1, Juliana Cardoso Sandes Faria1, Bruno Lima Rodrigues2*

One of the many types of scarring alopecia is Frontal Fibrosing Alopecia (FFA), which is especially common in post-menopausal women. It presents a variety of clinical manifestations and is characterized by a distinct clinical pattern of progressive recession involving the frontotemporal and parietal hairline. Its aetiology is still poorly understood, but autoimmune, hormonal, genetic, inflammatory, behavioural and environmental factors are thought to be important in its aetiology. Alternatives to these approaches are also regenerative, including the use of Platelet- Rich Plasma (PRP) and Polydeoxyribonucleotides (PDRN), which exhibit immunoregulatory and tissue remodelling functions. This study aimed to describe a regenerative intervention in a case of frontal fibrosing alopecia in a female patient whose clinical examination revealed significant hairline recession and bitemporal skin atrophy. The proposed treatment consisted of six sessions of intradermal therapy with PRP associated with PDRN. Additionally, the patient was treated with minoxidil 2.5 mg/day, dutasteride 0.5 mg/day and hydroxychloroquine 400 mg/day. When the patient returned after six months, the area of atrophy was much improved, perifollicular scaling at the hairline and vellus hair had not recurred, and there was no sign of inflammation in the eyebrow area. The results strongly suggest that early diagnosis and therapy capable of limiting the inflammatory process, such as regenerative approaches, are important to preventing FFA's progression.