血液病与血栓栓塞疾病杂志
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Zinc Supplementation to Combat Infections in Children with Sickle Cell Anemia

Benjamin Grimmer1*, Ioana Stanescu2, Petra Staubach2, Derval Carroll1, Kelvin Yeung1,2, Eleni Louker2

Sickle Cell Anemia (SCA) is a global genetic disorder, prevalent primarily in Sub-Saharan Africa, where it significantly contributes to childhood mortality. Infections are a major threat to individuals with SCA, emphasizing the urgent need for effective preventive strategies. Zinc deficiency, prevalent in SCA patients, compromises immune function, making them susceptible to infections. While zinc supplementation has shown promise in older individuals, its efficacy in children under five with SCA remains unexplored. This study addresses a critical knowledge gap in preventing infections in young children with SCA, with the potential to transform clinical practice, save lives, and improve the health of affected children, not only in Uganda but also in other regions heavily affected by this disease.