免疫遗传学:开放获取

免疫遗传学:开放获取
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非诺贝特、阿托伐他汀和依折麦布致自身免疫样药物性肝损伤一例

胡科杰*、王玉芳、何亚红、熊家斌

In recent years, Drug-Induced Liver Injury (DILI) has become a significant concern due to its potential for severe liver damage. We present a case report of autoimmune-like DILI caused by the concomitant use of fenofibrate, atorvastatin and ezetimibe. Glucocorticoid therapy has been proven to be effective. The patient was monitored for an additional 3 years and no changes were observed. Additionally, we provide a comprehensive literature review on similar cases to enhance our understanding of this rare adverse drug reaction. This case highlights the importance of considering autoimmune-like DILI as a potential diagnosis in patients presenting with liver injury and positive autoantibodies. Healthcare professionals should be aware of the potential hepatotoxicity associated with fenofibrate, atorvastatin and ezetimibe. Early recognition and prompt withdrawal of the offending medications, along with appropriate immunosuppressive therapy, can lead to favorable outcomes in patients with autoimmune-like DILI.

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