蛋白质组学与生物信息学杂志
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纳米病毒科纳米生物MHC结合肽和表位的预测与比较分析

Dangre DM、Deshmukh SR、Rathod DP、Umare VD 和 Ullah I

Nanoviridae is a family of single stranded DNA viruses which infect the plants through their phloem tissues. The few members of these viruses are now turning towards animals. It includes two genera, Nanovirus and Babuvirus. Nanovirus includes three species namely Faba beans necrotic yellows virus (FBNYV), Milk vetch dwarf virus (MVDV) and Subterranean clover stunt virus (SCSV) while Babuvirus have two species accounted yet, namely Abaca bunchy top virus (ABTV) and Banana bunchy top virus (BBTV). The viral coat proteins are likely to be responsible for many diseases in plants as well as animals. The intra-genomic changes or post translational modifications with in SCSV have decreased the length of the sequence, but increased the antigenic potential and numbers of antigenic binding regions on the surface of the protein. We have predicted the most probable responsible antigenic determinants and MHC binders within the viruses in Nanoviridae family. MHC molecules play a crucial role in host immune response. The nonamers of antigenic determinants in Nanoviridae family viral coat proteins are highly sensitive to H-2Kd and I-Ag7 molecules. The species within particular genera shows their common 表位以及不同的同事表位。这些常见的抗原肽可以作为它们的标识符。这些标识符及其不同的同事可能为针对自身的解毒剂生产提供最丰富的信息。此外，这些对于针对相关病毒的合成肽疫苗的生产也很重要。