临床毒理学杂志
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A Case of 40-Year Old Man with Organophosphate Poisoning that his Nicotinic Symptoms Responded Dramatically to Magnesium Sulphate

Arman Hakemi

Organophosphates are chemicals used in pesticides. These compounds are acetylcholinesterase inhibitors and prevent the breakdown of acetylcholine. The accumulation of acetylcholine leads to the activation of muscarinic receptors and the creation of cholinergic effects, including increased secretions. It also causes overstimulation of nicotinic receptors, which can lead to respiratory arrest, which is the most common cause of death in organophosphate poisoning. Drug treatment is with atropine and enzyme activator such as pralidoxime. In this study, we presented a 40-year-old man who presented to the emergency room due to suicide with organophosphate poisoning, who was successfully treated with a combination of atropine and magnesium sulfate instead of pralidoxime.