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Advances in the Study of B-Cell Receptors: From Tumor Characteristics to Clinical Applications

Runze Jiang*, Lin Bai, Mingwei Wang, Shuai Li

Hepatocellular Carcinoma (HCC) is a global malignant tumor and its complex tumor microenvironment and immune escape mechanism pose great challenges for treatment. In recent years, B-Cell Receptor (BCR) has become a focus of research because of its central role in adaptive immunity. We not only summarize the specific changes of BCR in HCC but also demonstrate that BCR can be considered as a potential biomarker for tumor diagnosis and prognosis prediction. In the future, through the integration of multi-omics data and the mining of the synergistic effect of BCR and T-Cell Receptor (TCR), it is expected to reveal the panorama of the HCC immune microenvironment and promote the clinical transformation of BCR in HCC diagnosis and treatment.