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Importance of Heart-Type Fatty Acid-Binding Protein Combined with Creatinine Kinase and Homocysteine in Determining the Severity of Acute Poisoning

Xikai Wang, Jingjing Ma, Yanli Wang

Background: This study aimed to assess the importance of Heart-type Fatty Acid-Binding Protein (H-FABP), Creatinine Kinase (CK) and Homocysteine (Hcy) in determining the severity of acute poisoning.

Materials and methods: 224 poisoning patients were divided into four observed groups-Carbon monoxide (CO), alcohol, pesticide and drug, 50 health people as control group were included in this study. The patients were diagnosed moderate or severe acute poisoning. Blood samples were collected at the time of admission and the HFABP, CK and Hcy of serum were tested at the time point.

Results: All the four observed groups of patients, the average H-FABP, CK and Hcy levels were significantly higher than those of the control group. We found H-FABP combined with CK had a statistically correlation between the moderate and severe of acute CO and pesticide poisoning, H-FABP combined with Hcy had a significantly correlation between the moderate and severe of acute alcohol poisoning, H-FABP combined with CK and Hcy had a significantly correlation between the moderate and severe of acute drug poisoning. Receiver Operating Characteristic (ROC) curve showed that the combination of three biomarkers could improve the diagnostic ability of the type and severity of acute poisoning.

Conclusion: H-FABP combined with CK and Hcy in determining the type and the severity of acute poisoning has an important value.